It is the most frequent giant cell lesion of the jaws, and originates from the connective tissue of the periosteum or from the periodontal. A definite geographic variation has been observed in the frequency of odontogenic tumors and giant cell lesions of the jaws reported from different parts of the world. Central giant cell granuloma, benign jaw tumor, molar, recurrent pericoronitis, multinucleated giant cells. Central giant cell granuloma is a benign intraosseous lesion of the jaws. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. Discussion the central giant cell granuloma is a benign. Giant cell reparative granuloma, features of cgcg is its ability to cross the midline of the traumatic bone cyst and fibrous fibrooseous mandible. Article information, pdf download for central giant cell granuloma of the jaws. Central giant cell granuloma of the jaws regress with calcitonin therapy. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. The term giant cell reparative granuloma gcrg was first used by jaffe in 1953, to distinguish these lesions from giant cell. A retrospective analysis of a 20year database was performed regarding both clinical and radiological features of 22 patients affected with cgcgs of the jaws.
Jul 29, 2009 shows preop considerations, the operative removal, and properties of the giant cell granuloma. Central giant cell granuloma was classified by the world health organization in 2005 as a rarely aggressive idiopathic benign intraosseous lesion that occurs almost exclusively in the jaws. It is an uncommon, benign and proliferative non neoplastic process. The diagnosis and management of giant cell lesions of the jaws ncbi. The concept at that time was that these lesions only seemed to occur in the jaws, they were found in the first two decades of life, more frequently in females approximately 2. Central giant cell granuloma of the jaws and giant cell tumor of long. Central giant cell granuloma of the jaws and giant cell. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. In spite of that, these questions remain unclear 11,16,23,26 morphologic studies performed in order to compare cgcg and gct features have. Central giant cell granuloma of the jaws and giant cell tumor of long bones. The concept at that time was that these lesions only seemed to occur in the jaws.
However, aneurysmal bone cyst shows bloodfilled cystic cavities. The term giant cell lesion gcl defines a group of intraosseous nonodontogenic benign lesions with multinucleated giant cells gcs. Central giant cell granuloma is considered widely to be nonneoplastic lesion. The microscopic appearance of the central giant cell. Several entities in the jaws can share this histology, including hyperparathyroidism, cherubism and the central giant cell granuloma cgcg 1. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Central giant cell granuloma, fibrous dysplasia introduction central giant cell granuloma and fibrous dysplasia are relatively uncommon lesions1. Uses microscopic slides and shows postops of 1,4,and 7 months. Hence, this study was designed to provide a demographic data on the odontogenic tumors and giant cell lesions reported from.
Central giant cell granuloma was first described by jaffe in 1953. A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor. Central giant cell granuloma cgcg has unpredictable biologic behavior, nonspecific radiographic features and is amenable to a plethora of treatment alternatives. Radiological and epidemiological aspects of central giant cell. It is twice as common in females and is more likely to occur before age 30. The central giant cell reparative granuloma of the jaws.
A case of a 31yearold caucasian female with multiple recurrent central giant cell granulomas of the maxilla and mandible is presented. Radiographic features of central giant cell granuloma of. Central giant cell granuloma of the jaws and giant cell tumor of long bones are wellrecognized entities revealing benign nature 16. Gcrg is an uncommon benign lesion that is most commonly found in the mandible and maxilla. It was formerly regarded as reparative process and was accordingly called central giant cell reparative granuloma 35. Central giant cell granuloma of the mandible youtube. However, most authorities believe peripheral giant cell granuloma is a reactive lesion. The central giant cell lesion of the jaw is a rare benign tumour with an unknown aetiology accounting for up to 7% of tumours in the mandible lower jaw and the maxilla upper jaw. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. The radiographic features of ten pediatric cases of central giant cell granuloma of the jaws were studied, using plain film radiography pfr, computed tomography ct, and a dental ct software program. This patient report describes a recurrent central giant cell granuloma. It is the most frequent giant cell lesion of the jaws.
Central giant cell granuloma of the jaws and giant cell tumor of long bones an immunohistochemical comparative study. Ct and mr imaging of giant cell granuloma of the craniofacial. Its etiology is unknown and its biological behavior is poorly understood. Radiographic features of central giant cell granuloma of the. Central giant cell granuloma appears references as poorly defined unilocular radiolucency or multilocular radiolucency with scalloped borders. Teeth or root displacement was found as the most consistent feature. Multiple recurrent central giant cell granulomas of the. Case report giant cell tumor of the maxilla in an 8 year old boy.
They result from a local inflammatory process, thought to be secondary to trauma. It occurs most frequently in young women aged central giant cell granuloma of the jaws and giant cell tumor of long bones are wellrecognized entities revealing benign nature16. Apr 17, 2015 central giant cell granuloma was 1st described in jaws by jaffe 1953. A case of 19yearold male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. We report an unusual case of giant cell reparative granuloma gcrg arising in the nasal cavity of a 7yearold girl. Odontogenic tumors and giant cell lesions of jaws a nine. This patient report describes a recurrent central giant cell granuloma involving the body of the mandible in a 48yearoldwoman. This group of lesions includes central giant cell granuloma cgcg, giant cell tumor.
Central giant cell granuloma cgcg is a benign, proliferative, intraosseous and nonodontogenic lesion of unknown etiology. The term central giant cell lesion has been proposed as a microscopic feature and not those of a true granulomatous process. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma. Traditional treatment has been local curettage, although aggressive subtypes. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. Follow up of one year was done and during this period no recurrence of the lesion was noticed fig5. Giant cell granuloma an overview sciencedirect topics. The purpose of present study was to investigate and correlate the histological findings in central giant cell granuloma and peripheral. Central giant cell granuloma cgcg is a localised benign condition of the jaws.
This condition is a slowgrowing, asymptomatic lesion that usually affects children and young adults, predominantly females. A clinicopathological, cytometric and immunohistochemical comparative study manal a al sheddi 1, hezekiah a mosadomi 2, fh al dayel 3. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Giant cell reparative granuloma of the nasal cavity. Their clinical behavior8,29, prognostic factors and the. A reactive response to trauma is the most accepted etiopathogenesis of cgcg 1 3. Central giant cell granuloma is considered widely to be nonneo. This case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Aggressive central giant cell granuloma of the mandible, a. The radiographic features of ten pediatric cases of central giant cell granuloma of the jaws were studied, using plain film radiography pfr, computed tomography ct, and a dental ct software program ds. Interventions for central giant cell granuloma of the jaws. Full text pimary hyperparathyroidism as central giant. Peripheral giant cell granuloma pgcg is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely.
Management of central giant cell granulomas of the jaws. Traditional treatment has been local curettage, although aggressive subtypes have a high tendency to recur. Their clinical behavior8,29, prognostic factors and the histogenesis have been subject of several studies. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. Aggressive central giant cell granuloma mimicking peripheral. The most common treatment is curettage,which has a high recurrence rate, particularly in more. Peripheral giant cell granuloma in anterior maxilla. Peripheral giant cell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Giant cell lesions of the jaws were separated out from other jaw lesions by jaffe in 1953 when they were termed giant cell reparative granulomas. The diagnosis and management of giant cell lesions of the jaws.
The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and. Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. A second tomography revealed an osteolytic lesion in the right mandible. Pdf central giant cell granuloma of the jaws and giant cell. Gcrg is an uncommon benign lesion that is most commonly found in the. After this the lesion was completely excised and thorough curettage of the area was done under general anesthesia fig4. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. Central giant cell granuloma and fibrous dysplasia occurring in the same jaw is rarely reported in the literatures. An aggressive central giant cell granuloma in a pediatric patient.
The objective was to investigate the clinical and radiological characteristics of central giant cell granulomas cgcgs of the jaws. Pdf central giant cell granuloma of the jaws and giant. Four months after surgery, a mass was observed on the same site. Giant cell granulomas are benign intraosseous lesions, typically occurring in young females. It is by far the most common of giant cell lesions of jaws. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. Peripheral giant cell granuloma pgcg is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. Giant cell granuloma was described as an idiopathic nonneoplastic proliferative lesion and termed a reparative granuloma. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the.
The aim of this study was to compare cgcg of the jaws and gct of long bones from clinicopathology, cytometry and immunohistochemistry aspects. Central giant cell granuloma of the jaws and giant cell tumor. The aim of this study was to compare cgcg of the jaws. Central giant cell granuloma venkateshwarlu et, al 6. Radiographs of a biopsyproven central giant cell granuloma of the left anterior mandible in a 23yearold female a represents the lesion at the time of biopsy and. Cgcg was formerly regarded as a reparative process and was, accordingly, called central giant cell reparative granuloma. These include giant cell tumor, cherubism, aneurysmal bone cyst and jaw tumor of hyperparathyroidism venkateshwarlu et al. Fourteen women and 8 men were included with the age range of 781 years mean 31. Numerous giant cell rich lesions of jaws could be considered in the differential diagnosis. Histological evaluation of the possible transformation of peripheral giant cell granuloma. The microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in hyperpituitarism.
Familial cases of giant cell granulomas reported by waldron 1951, and by brannin and christen multiple recurrent central giant cell granulomas of the jaws 129 table 1 laboratory data. Central giant cell granuloma appears to be lesion that is unique to the jaws. Peripheral giant cell granuloma in a child associated with. Aggressive variant of central giant cell granuloma austin.
The microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in for which of the following pathological conditions would a lower central incisor tooth be expected to respond to heat, cold and electric pulp test. A clinical, radiologic and histopathologic study of 26 cases ooo 2006. Their clinical behavior 8,29, prognostic factors and. Unusual aggressive behavior of central giant cell granuloma. Central giant cell granuloma was 1st described in jaws by jaffe 1953. Also called giant cell reparative granuloma central if intraosseous. Recurrent central giant cell granuloma in the mandible. Radiographic examination orthopantograph and 3dct showed large multilocular radiolucency in right. The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. Central giant cell granuloma of the jaws and giant cell tumor of long bones are wellrecognized entities revealing benign nature16. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws.
Central giant cell granuloma cgcg of the jaws and giant cell tumor gct of bone share a number of similarities and dissimilarities in respect of their histopathological, cytometric and immunohistochemical features. The lesions occur more frequently in females than in males and are more often located in the. It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. It affects females more often than males, mandible than. Shows preop considerations, the operative removal, and properties of the giant cell granuloma. This report describes the clinical and histopathological findings of a pgcg diagnosed in the maxilla of a 9yearold boy associated with a tooth erupting improperly and a. The clinical behavior of cgcg of the jaws is variable and difficult to predict. Central giant cell granuloma and fibrous dysplasia occurring. Interventions for central giant cell granuloma of the jaws the central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. The patients mother was also treated for an extensive giant cell granuloma of the maxilla. The microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in hyperpituitarism pagets disease hyperparathyroidism cleidocranial dysplasia. Multiple recurrent central giant cell granulomas of the jaws. Central giant cell granuloma of the mandibular condyle. Giant cell granuloma,maxilla,benign lesion, surgical excision, corticosteroid injection, unusual etiology introduction giant cell granuloma is a rare bony lesion in the head and neck.
Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. Central giant cell granuloma cgcg is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Surgical curettage was again carried out, and the pathological diagnosis was fibroses, which did not confirm the possibility of recurrence. The diagnosis and management of giant cell lesions of the. Central giant cell granuloma and fibrous dysplasia. Pimary hyperparathyroidism as central giant cell granuloma of the jaws. Jun 19, 2018 the peripheral giant cell granuloma has an unknown etiology, with some dispute as to whether this lesion represents a reactive or neoplastic process. The central giant cell granulomacgcg of bone constitutes about 10% of benign jawbone lesions.
It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells. The radiologic features varied from illdefined destructive lesions to a welldefined, multilocular appearance. Aggressive central giant cell granuloma of the mandible, a diagnostic dilemma pavitra baskaran 1, margathavalli gopal 2, varun rastogi 3, satya ranjan misra 4 1 department of oral medicine and radiology, saveetha dental college and hospitals, chennai, tamil nadu, india 2 department of oral medicine and radiology, meenakshi ammal dental college, chennai, tamil nadu, india 3 department of oral. Case report giant cell tumor of the maxilla in an 8 year. Central giant cell granuloma of the mandible american. In spite of that, these questions remain unclear 11,16,23,26. Cgcg is a nonneoplastic lesion of the jaws4 that can present different. Central giant cell granuloma cgcg is a lesion that appears to be unique to the jaws, 1115 although the socalled giant cell reaction of the hands and feet shares many features. Clinicopathological profile of central giant cell granulomas. These include giant cell tumor, cherubism, aneurysmal bone cyst and jaw tumor of hyperparathyroidism. Full text pimary hyperparathyroidism as central giant cell. The central giant cell granuloma cgcg was first described by jaffe in 1953 as a giant cell reparative granuloma of the jaw bones. However, there are a few studies on these lesions, especially giant cell lesions, reported from india.
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